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Ultracol 100 vs 200: What Is the Difference?

The difference between Ultracol 100 and 200 (PDO dose and particle size), how to choose according to the skin concern, and the treatment interval and aftercare.

Published 2026-11-02 Updated 2026-11-02 Reviewed by Hyeran Heo, Medical Director

Ultracol 100 and 200 are easily misunderstood, as if a higher number meant a better product, but the difference between the two lies not in grade but in PDO dose and particle size. Ultracol 100 often suits concerns about fine lines and skin texture, while Ultracol 200 often suits concerns about deep wrinkles and volume. This article sets out how the two products work, how they differ, how to choose between them and the treatment interval.

01

How does Ultracol work?

Key point
Ultracol is a treatment that uses a collagen production stimulator made from the ingredient PDO, which stands for polydioxanone. After the PDO is injected into the dermis, it stimulates the fibroblasts in that layer of the skin and, as time passes, induces new collagen to be produced there.

PDO, the main ingredient of Ultracol, is commonly used in thread lifting; it is highly biocompatible and stimulates fibroblasts when injected into the dermis. In a way similar to how collagen is produced as the threads dissolve and disappear in thread lifting, Ultracol is also a treatment that induces collagen production over time.

Behind the attention collagen boosters are receiving is a change in how fillers are perceived. Fillers have long been used for hollow areas, but more people now want changes that are not noticeable because fillers can feel artificial or like a foreign body, and in many cases they have turned to collagen boosters as an alternative.

Anatomy illustration related to Ultracol 100 vs 200: What Is the Difference?
02

What is the difference between Ultracol 100 and 200?

Key point
The difference between Ultracol 100 and 200 lies in the PDO dose and the particle size. Ultracol 100 has particles of 20 to 50 μm and Ultracol 200 has particles of 50 to 100 μm. The purpose of the treatment differs according to particle size, not according to whether the number is higher or lower.

The 100 and 200 in Ultracol are not grades but labels distinguishing PDO dose and particle size, in the same way that Juvelook Skin and Juvelook Volume are divided by particle size. The larger the particles, the more collagen is produced, while smaller particles allow delicate treatment of sensitive, thin skin.

If Ultracol 100 is chosen for a concern that needs Ultracol 200, the effect may not be as strong as expected. Because the suitable candidate differs by particle size, when the concern is clear, such as deep wrinkles around the nasolabial folds, the product should be decided after an in-depth consultation with the medical team.

  • Ultracol 100 particles — small at 20 to 50 μm, allowing delicate treatment of thin skin
  • Ultracol 200 particles — larger at 50 to 100 μm, producing more collagen
  • What the two products share — both are PDO-based, and the difference lies in dose and particle size
03

When is Ultracol 100 or 200 the right choice?

Key point
For concerns about skin texture, fine lines and pores, Ultracol 100 is often the suitable choice, while for concerns involving a lack of volume, such as deep nasolabial folds or hollow cheeks, Ultracol 200 is often suitable. The final choice is made after looking at the condition of the skin.

Ultracol 100 is mainly used for fine lines, rough skin texture and enlarged pores in thin, delicate areas such as around the eyes, around the mouth and the neck. Ultracol 200 is used on nasolabial folds, hollow cheeks and under-eye grooves, with the aim of improving deep wrinkles, adding volume and refining contours.

Where needed, Ultracol can be combined with other skin boosters or lifting treatments for more efficient care. However, rather than simply following a product that others have recommended, it is advisable to first check one's own skin condition and the desired change, and then decide on the treatment combination.

  • Concerns for Ultracol 100 — chosen for skin tone, rough texture, fine lines and enlarged pores
  • Areas for Ultracol 100 — used on thin, delicate areas such as around the eyes, around the mouth and the neck
  • Concerns for Ultracol 200 — chosen when volume is lacking, as with deep nasolabial folds or hollow cheeks
04

How many Ultracol sessions are needed, and at what interval?

Key point
Ultracol is usually given about 3 times at intervals of 4 weeks, and after that the treatment is repeated every 6 months to maintain the effect. Collagen forms gradually from 4 to 6 weeks after the treatment, and there are differences from person to person.

Ultracol is a treatment in which collagen forms gradually from around 4 to 6 weeks after the treatment. The average schedule is about 3 sessions at intervals of around 4 weeks at first, followed by a session every 6 months to maintain the effect, but because there are individual differences, a treatment plan suited to each person needs to be made separately.

Because Ultracol is basically given by injection and puts stress on the skin, it is advisable to avoid drinking and smoking as much as possible after the treatment. Applying sunscreen without fail to protect the skin from ultraviolet rays is also basic aftercare to follow after the treatment.

Hyeran Heo, Medical Director
Doctor's view

How the doctor decides

Hyeran Heo, Medical Director

I do not say the higher number is better

I am often asked which is better, Ultracol 100 or 200. I explain the difference between the two products not as one being superior to the other but as a difference in PDO dose and particle size. This is because choosing 200 for someone concerned about fine lines, or 100 for someone concerned about deep nasolabial folds, leaves the purpose and the product mismatched.

I look at the area of concern before the product name

When a patient tells me the concern directly, such as deep wrinkles around the nasolabial folds, the direction of treatment becomes clearer. So I first ask which change in which area is the concern, and accordingly I choose between Ultracol 100 and 200 or consider combining it with other skin boosters or lifting.

I do not apply the average schedule as it is

What I always ask of patients is to choose a treatment that suits their own skin condition and goals. The schedule of 3 sessions at 4-week intervals followed by every 6 months is also an average figure, so I set a plan suited to each person after checking the skin condition. I hope patients will not make a hasty decision just because others say a product is good.

Summary

In summary

Ultracol 100 and 200 are collagen boosters with the same PDO ingredient, but their particle sizes differ, so the concerns and areas they are used for are divided. The basic direction is 100 for skin texture and fine lines, and 200 for deep wrinkles and volume. If the artificial feel of fillers is a concern, or if it is hard to choose the right product, a medical consultation is recommended.

FAQ

Frequently asked questions

QDoes a higher Ultracol number mean a stronger effect?
A

No. Ultracol 100 and 200 differ in PDO dose and particle size, and the suitable product depends on the area of concern.

QDoes Ultracol show results right after the treatment?
A

Ultracol is a treatment that induces collagen production, so the change appears gradually. Collagen usually begins to form from 4 to 6 weeks after the treatment.

QIs there anything to be careful about after Ultracol?
A

Because the injection puts stress on the skin, drinking and smoking are avoided as much as possible. Sunscreen should also be used without fail.

Hyeran Heo, Medical Director
Medical review
Hyeran Heo, Medical Director
This content is general medical information and may not apply to every individual. Diagnosis and treatment are decided through a consultation.